ABSTRACT

A study on the effects of extruded sorghum bran (ESB) or raw sorghum bran (RSB) on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Four groups of male Wistar rats (six per group) consumed a basal diet (BD), which were supplemented with either lard at 310 g/kg (HFD) or lard and ESB at 180 g/kg (HFD + ESB) or lard and RSB (HFD + RSB), for 8 weeks. The intake of HFD supplemented with ESB or RSB hindered the fat storage in adipocytes of abdominal tissue, dyslipidemia and the loss of glucose homeostasis. A positive correlation between inflammation biomarkers (Interleukin-1β and Interleukin-6) and glucose homeostasis was observed, while a negative correlation between antioxidant capacity (TEAC) and Interleukin-1β and Interleukin-6 was observed. As a conclusion, the ESB or RSB may be intended as part of healthy diets.

摘要

进行了高粱麸皮（ESB）或生高粱麸皮（RSB）的挤压对高脂饮食（HFD）诱导的大鼠葡萄糖失调，血脂异常，炎症和抗氧化潜力生物标志物的影响的研究。四组雄性Wistar大鼠（每组六只）进食基础饮食（BD），并补充猪油310 g / kg（HFD）或猪油和ESB 180 g / kg（HFD + ESB）或猪油和RSB（HFD + RSB），持续8周。补充ESB或RSB的HFD的摄入会阻碍腹部组织脂肪细胞中的脂肪存储，血脂异常和葡萄糖稳态的丧失。炎症生物标志物（白细胞介素-1β和白细胞介素-6）与葡萄糖稳态之间呈正相关，而抗氧化能力（TEAC）与白细胞介素-1β和白细胞介素-6之间呈负相关。