Abstract A one pot procedure was used to synthesize two new derivatives of α-aminophosphonates. Novel copper(II) complexes of α-aminophosphonates were synthesized by coordinating different copper salts with the newly synthesized α-aminophosphonates. Their structures were characterized by different spectral and analytical techniques. Evaluation of the metal-free ligands HL1, HL2, and their Cu(II) complexes against human colon carcinoma HT-29 cell lines was performed, using cisplatin as a reference drug. The results indicated that the complexes of the ligand HL1 exhibited enhanced anticancer activity, while ligand HL2 complexes showed decreased anticancer activity. Graphical Abstract

中文翻译：

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α-氨基膦酸盐的过渡金属配合物第二部分：α-氨基膦酸盐铜（II）配合物的合成、光谱表征和体外抗癌活性

摘要 采用一锅法合成了α-氨基膦酸酯的两种新衍生物。通过将不同的铜盐与新合成的 α-氨基膦酸盐配位，合成了 α-氨基膦酸盐的新型铜 (II) 配合物。它们的结构由不同的光谱和分析技术表征。使用顺铂作为参考药物，对无金属配体 HL1、HL2 及其 Cu(II) 复合物对人结肠癌 HT-29 细胞系进行了评估。结果表明配体HL1的配合物抗癌活性增强，而配体HL2的配合物抗癌活性降低。图形概要