Electroconvulsive therapy (ECT) is a highly effective and fast-acting treatment for depression used in the clinic. Its mechanism of therapeutic action remains uncertain. Previous studies have focused on documenting neuroplasticity in the early phase following electroconvulsive seizures (ECS), an animal model of ECT. Here, we investigate whether changes in synaptic plasticity and nonneuronal plasticity (vascular and mitochondria) are sustained 3 months after repeated ECS trials.

中文翻译：

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反复电惊厥发作后大鼠海马结构的持续超微结构变化。

电休克疗法 (ECT) 是临床上用于抑郁症的一种高效且快速的治疗方法。其治疗作用机制仍不确定。以前的研究集中在记录电痉挛性癫痫发作 (ECS)（一种 ECT 动物模型）后早期的神经可塑性。在这里，我们调查突触可塑性和非神经元可塑性（血管和线粒体）的变化是否在重复 ECS 试验后持续 3 个月。