Post traumatic stress disorder (PTSD) is widely regarded as a stress-related and trauma disorder. The symptoms of PTSD are characterized as a spectrum of vulnerabilities after the exposure to an extremely traumatic stressor. Considering as one of complex mental disorders, little progress has been made toward its diagnostic biomarkers, despite the involvement of PTSD has been studied. Many studies into the underlying neurobiology of PTSD implicated the dysfunction of neurosteroids biosynthesis and neuorinflammatory processes. Translocator protein 18 kDa (TSPO) has been considered as one of the promising therapeutic biomarkers for neurological stress disorders (like PTSD, depression, anxiety, et al) without the benzodiazepine-like side effects. This protein participates in the formation of neurosteroids and modulation of neuroinflammation. The review outlines current knowledge involving the role of TSPO in the neuropathology of PTSD and the anti-PTSD-like effects of TSPO ligands.

中文翻译：

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易位蛋白 18 kDa：创伤后应激障碍的潜在治疗生物标志物。

创伤后应激障碍（PTSD）被广泛认为是一种与压力相关的创伤障碍。创伤后应激障碍的症状表现为暴露于极度创伤性压力源后的一系列脆弱性。作为一种复杂的精神障碍，尽管研究了 PTSD 的参与，但在其诊断生物标志物方面进展甚微。许多对 PTSD 潜在神经生物学的研究都涉及神经类固醇生物合成和神经炎症过程的功能障碍。易位蛋白 18 kDa (TSPO) 被认为是神经应激障碍（如 PTSD、抑郁、焦虑等）的有前途的治疗生物标志物之一，没有苯二氮卓样副作用。这种蛋白质参与神经类固醇的形成和神经炎症的调节。