The main function of brown adipose tissue (BAT) is thermogenesis, a process mediated by uncoupling protein 1 (UCP1), which is located in the inner mitochondrial membrane and acts uncoupling oxidative phosphorylation from ATP production, thereby dissipating energy as heat. White adipose tissue can also express UCP1 positive cells due to a process known as browning. This phenomenon could also increase the thermogenic effect in the classical brown adipose depots. BAT thermogenesis depends, among other factors on both, nutritional conditions and food availability. Indeed, some studies have found that BAT recruitment and function are enhanced by some food components. The present study focuses on the effects of resveratrol and pterostilbene, two phenolic compounds belonging to the stilbene group, on BAT thermogenic activation and white adipose tissue browning process. The reported studies, carried out in cell cultures and animal models, show that both resveratrol and pterostilbene induce thermogenic capacity in interscapular BAT by increasing mitochondriogenesis, as well as enhancing fatty acid oxidation and glucose disposal. In addition, resveratrol seems to promote browning by activating peroxisome proliferator-activated receptor (PPAR), while the lack of changes in mitochondrial biogenesis suggests that probably the browning process occurs by direct resveratrol-mediated upregulation of ucp1 mRNA expression.

中文翻译：

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白藜芦醇及其衍生物蝶粉对棕色脂肪组织的热激活和白色脂肪组织褐变的影响。

棕色脂肪组织（BAT）的主要功能是生热，这是由解偶联蛋白1（UCP1）介导的过程，该蛋白位于线粒体内膜上，并与ATP产生的氧化磷酸化解偶联，从而将能量作为热量消散。由于称为褐变的过程，白色脂肪组织也可以表达UCP1阳性细胞。这种现象也可能会增加经典棕色脂肪库的产热效应。BAT的热生成除其他因素外，还取决于营养条件和食物供应。确实，一些研究发现，某些食物成分可提高BAT的募集和功能。本研究的重点是白藜芦醇和萜烯二萜（属于二苯乙烯类的两种酚类化合物）的作用，对BAT的热激活和白色脂肪组织褐变的影响。在细胞培养物和动物模型中进行的报道的研究表明，白藜芦醇和萜烯二烯都能通过增加线粒体生成以及增强脂肪酸氧化和葡萄糖处理来诱导肩inter间BAT的产热能力。此外，白藜芦醇似乎通过激活过氧化物酶体增殖物激活受体（PPAR）促进褐变，而线粒体生物发生变化的缺乏表明褐变过程可能是由白藜芦醇直接介导的上调引起的。以及增强脂肪酸氧化和葡萄糖处置。此外，白藜芦醇似乎通过激活过氧化物酶体增殖物激活受体（PPAR）促进褐变，而线粒体生物发生的变化缺乏表明褐变过程可能是由白藜芦醇直接介导的上调引起的。以及增强脂肪酸氧化和葡萄糖处置。此外，白藜芦醇似乎通过激活过氧化物酶体增殖物激活受体（PPAR）促进褐变，而线粒体生物发生变化的缺乏表明褐变过程可能是由白藜芦醇直接介导的上调引起的。ucp1 mRNA表达。