Purpose of Review

Sickle cell disease (SCD) is a hematological disorder which leads to serious complications in multiple organ systems. While significant research has addressed many of the effects of acute pain episodes and end-organ damage connected to this disease, little has approached the chronic pain state associated with this condition.

Recent Findings

Associated chronic pain represents a significant detractor from the quality of life experienced by these patients, affecting over half of those with SCD on more days than not. Current treatment typically is centered upon preventing and responding to acute vasoocclusive crises, presumably because this is the most common reason for hospitalization in these patients. The lack of management of chronic pain symptoms leaves many with SCD in a state of suffering.

Summary

In this review, the treatment methodologies of SCD patients are examined including alternative treatments, both pharmaceutical and non-pharmaceutical, as well as procedural approaches specifically aimed at reducing chronic pain in these patients.

中文翻译：

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镰状细胞病疼痛的治疗和管理的全面综述。

审查目的

镰状细胞病（SCD）是一种血液疾病，会导致多器官系统严重并发症。尽管大量研究已经解决了与这种疾病有关的急性疼痛发作和终末器官损害的许多影响，但很少有人能找到与此疾病相关的慢性疼痛状态。

最近的发现

伴随的慢性疼痛严重影响了这些患者的生活质量，超过半数的患者受到SCD影响的时间超过了一半。当前的治疗通常集中在预防和应对急性血管闭塞性危机，大概是因为这是这些患者住院的最常见原因。慢性疼痛症状缺乏管理，使许多人处于患病状态。

概要

在这篇综述中，研究了SCD患者的治疗方法，包括药物和非药物的替代治疗，以及专门旨在减轻这些患者慢性疼痛的程序方法。