Progress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. However, there is a risk of re-emergence if the factors fueling transmission are not dealt with. Although it is essential to understand these underlying factors for each disease, asymptomatic carriers are a common element that may promote resurgence; their impact in terms of proportion in the population and role in transmission needs to be determined. In this paper, we review the current evidence on whether or not to treat asymptomatic carriers given the relevance of their role in the transmission of a specific disease, the efficacy and toxicity of existing drugs, the Public Health interest, and the benefit at an individual level, for example, in Chagas disease, to prevent irreversible organ damage. In the absence of other control tools such as vaccines, there is a need for safer drugs with good risk/benefit profiles in order to change the paradigm so that it addresses the complete infectious process beyond manifest disease to include treatment of non-symptomatic infected persons.

中文翻译：

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无症状感染对选定寄生热带病自然史的影响。

在控制或消除热带病方面取得了进展，发病率显着下降。然而，如果不解决助长传播的因素，则存在重新出现的风险。尽管了解每种疾病的这些潜在因素至关重要，但无症状携带者是可能促进疾病复发的常见因素；需要确定它们在人口中的比例和在传播中的作用方面的影响。在本文中，我们回顾了关于是否治疗无症状携带者的当前证据，考虑到无症状携带者在特定疾病传播中的作用的相关性、现有药物的功效和毒性、公共健康利益以及对个人的益处例如，在恰加斯病中，可以防止不可逆的器官损伤。在缺乏疫苗等其他控制工具的情况下，需要具有良好风险/效益特征的更安全药物，以改变范式，使其解决除明显疾病之外的完整感染过程，包括对无症状感染者的治疗。