Angiogenesis is the growth of new capillaries from the preexisting blood vessels. Glioblastoma (GBM) tumors are highly vascularized tumors, and glioma growth depends on the formation of new blood vessels. Angiogenesis is a complex process involving proliferation, migration, and differentiation of vascular endothelial cells (ECs) under the stimulation of specific signals. It is controlled by the balance between its promoting and inhibiting factors. Various angiogenic factors and genes have been identified that stimulate glioma angiogenesis. Therefore, attention has been directed to anti-angiogenesis therapy in which glioma proliferation is inhibited by inhibiting the formation of new tumor vessels using angiogenesis inhibitory factors and drugs. Here, in this review, we highlight and summarize the various molecular mediators that regulate GBM angiogenesis with focus on recent clinical research on the potential of exploiting angiogenic pathways as a strategy in the treatment of GBM patients.

中文翻译：

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成人脑肿瘤中的肿瘤发展和血管生成：胶质母细胞瘤。

血管生成是从先前存在的血管中生长出新的毛细血管。胶质母细胞瘤 (GBM) 肿瘤是高度血管化的肿瘤，胶质瘤的生长依赖于新血管的形成。血管生成是一个复杂的过程，涉及血管内皮细胞（ECs）在特定信号刺激下的增殖、迁移和分化。它受其促进因素和抑制因素之间的平衡控制。已鉴定出各种刺激神经胶质瘤血管生成的血管生成因子和基因。因此，人们关注抗血管生成疗法，其中通过使用血管生成抑制因子和药物抑制新肿瘤血管的形成来抑制神经胶质瘤的增殖。在这里，在这篇评论中，