Abstract

Molecular recognition of simple sugars is crucial due to their essential roles in most living organisms. However, it remains extremely challenging to achieve a visual recognition of simple sugars like sucrose in water media under physiological conditions. In this article, the visual recognition of sucrose is accomplished by a chiral supramolecular hydrogel formation through the co-assembly of a two-component fibrous solution (l-phenylalanine based gelator co-diaminopyridine, LDAP) and sucrose. H-bonding between the amino group of LDAP and the hydroxyl group of sucrose facilitates the gelation by loading sucrose into the LDAP solution. The formed hydrogel showed an amplified inversion of circular dichroism (CD) signals as compared to the corresponding LDAP solution. In addition, the effective chirality transfer was accompanied by a bathochromic shift in UV–Vis and FL spectra of the gel. Such a simple and straightforward chiral co-assembled strategy to visually recognize sucrose will have the potential use of smart gelators in saccharides separation and proteomics to be further applied in medical diagnostics and cell imaging.

Graphic Abstract

中文翻译：

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超分子共组装的纤维材料中的手性传递，使蔗糖的视觉识别成为可能

摘要

简单糖的分子识别至关重要，因为它们在大多数生物中都起着至关重要的作用。然而，在生理条件下在水介质中实现对简单糖如蔗糖的视觉识别仍然极具挑战性。在本文中，蔗糖的视觉识别通过经由共组装的双组分纤维溶液的手性超分子水凝胶的形成（完成升-基于苯丙氨酸的胶凝剂共二氨基吡啶（LDAP）和蔗糖。LDAP的氨基和蔗糖的羟基之间的H键通过将蔗糖加载到LDAP溶液中来促进凝胶化。与相应的LDAP解决方案相比，形成的水凝胶显示出放大的圆二色性（CD）信号反转。另外，有效的手性转移伴随着凝胶的UV-Vis和FL光谱的红移。这种简单直观的手性共组装策略在视觉上识别蔗糖，将在糖分离和蛋白质组学中使用智能胶凝剂，并将其进一步应用于医学诊断和细胞成像。

图形摘要