Metastasis, which is closely linked to cancer-related deaths, is a highly complex process. It is an organ-specific process and involves interactions between the host and cancer cells. CXC chemokine receptor 4 is known to be expressed in various tumors and the binding with CXC ligand 12 induces signaling in cancer cell survival, migration, and proliferation. Particularly, the CXC chemokine receptor 4/CXC ligand 12 axis is known to promote the metastasis of breast cancer. Thus, agents that can downregulate CXC chemokine receptor 4 expression have potential against cancer metastasis. Minecoside is an active compound extracted from Veronica peregrina L. It is widely distributed in Korea and has been used as a traditional drug for the treatment of various chronic diseases. However, the anticancer and anti-inflammatory effects of minecoside have yet to be clarified. In this study, we found that minecoside downregulates constitutive CXC chemokine receptor 4 expression in MDA-MB-231 breast cancer cells. This downregulation also occurred at the transcriptional level. Minecoside-mediated suppression of CXC chemokine receptor 4 expression inhibited CXC ligand 12-induced invasion of breast and colorectal cancer cells. Overall, our results suggest that minecoside can be a novel anticancer agent that can inhibit cancer metastasis through inhibition of CXC chemokine receptor 4 expression.

中文翻译：

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Minecoside 通过调节乳腺癌和结肠癌细胞中 CXCR4 的表达来调节细胞侵袭

与癌症相关死亡密切相关的转移是一个高度复杂的过程。这是一个器官特异性过程，涉及宿主和癌细胞之间的相互作用。已知 CXC 趋化因子受体 4 在各种肿瘤中表达，与 CXC 配体 12 的结合诱导癌细胞存活、迁移和增殖的信号传导。特别地，已知CXC趋化因子受体4/CXC配体12轴促进乳腺癌的转移。因此，可以下调 CXC 趋化因子受体 4 表达的药物具有对抗癌症转移的潜力。Minecoside 是一种从 Veronica peregrina L 中提取的活性化合物，在韩国广泛分布，被用作治疗各种慢性病的传统药物。然而，minecoside的抗癌和抗炎作用尚未阐明。在这项研究中，我们发现 minecoside 下调 MDA-MB-231 乳腺癌细胞中组成型 CXC 趋化因子受体 4 的表达。这种下调也发生在转录水平。Minecoside 介导的 CXC 趋化因子受体 4 表达抑制抑制了 CXC 配体 12 诱导的乳腺癌和结肠直肠癌细胞侵袭。总的来说，我们的结果表明，minecoside 可以是一种新型抗癌剂，可以通过抑制 CXC 趋化因子受体 4 的表达来抑制癌症转移。Minecoside 介导的 CXC 趋化因子受体 4 表达抑制抑制了 CXC 配体 12 诱导的乳腺癌和结肠直肠癌细胞侵袭。总的来说，我们的结果表明，minecoside 可以是一种新型抗癌剂，可以通过抑制 CXC 趋化因子受体 4 的表达来抑制癌症转移。Minecoside 介导的 CXC 趋化因子受体 4 表达抑制抑制了 CXC 配体 12 诱导的乳腺癌和结肠直肠癌细胞侵袭。总的来说，我们的结果表明，minecoside 可以是一种新型抗癌剂，可以通过抑制 CXC 趋化因子受体 4 的表达来抑制癌症转移。