The co-evaporation method was used to synthesize the EN-β-CD@Piperine inclusion complex with a molar ratio of 1:1. The properties and structures of the inclusion complex were characterized by various methods to investigate the inclusion mode and interactions between host and guest. The results of molecular modeling were theoretically analyzed to determine the inclusion mechanism of inclusion complexes. Finally, the vitro dissolution release studies showed that the water solubility of piperine was significantly enhanced when EN-β-CD was combined with piperine. Therefore, the EN-β-CD@Piperine inclusion complex provides a promising development for the clinical application of piperine in the future.

中文翻译：

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胡椒碱与乙二胺-β-环糊精包合物的体外溶出度研究

采用共蒸发法合成了摩尔比为1:1的EN-β-CD@Piperine包合物。通过各种方法研究包合物的性质和结构，以研究主客体之间的包合模式和相互作用。对分子模拟的结果进行了理论分析，以确定包合物的包合机制。最后，体外溶出释放研究表明，当EN-β-CD与胡椒碱结合时，胡椒碱的水溶性显着增强。因此，EN-β-CD@Piperine包合物为未来胡椒碱的临床应用提供了广阔的发展前景。