Abstract

The carbonyl releasing Schiff base chelate derived Fe(III) complex has been synthesized following the simple wet chemical method. The rhombohedral packing of ligands with the metal ion in the complex was confirmed by its XRD pattern and FTIR spectrum. Compounds were characterized by UV-Vis., PL, FTIR, XRD and TEM techniques. Better biocompatibility of the complex than that of the pure Schiff base had been elaborated on gram-positive and gram-negative bacteria by Agar well disc-diffusion antibacterial screening. The complex also displayed pH-responsive in vitro anticancer therapy on MCF-7 breast cancer cells as revealed by MTT assay. The release of CO and Schiff base as well as the interaction of Fe(III) with the mitochondria inside the cell are the key factors of cell biocompatibility. This CORM complex had exhibited higher anticancer activity on MCF-7 cells than the Schiff base and thus potential candidate for the future biomedical applications.

Graphic abstract

New carbonyl releasing CORM-Schiff base complex of Fe(III) has been synthesized. This CO releasing complex exhibits rhombic packing, octahedral geometry and exhibits antimicrobial activity at 25 ppm concentration in water. The complex has good antimicrobial-anticancer potential.

中文翻译：

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Fe（III）的羰基释放席夫碱配合物：合成，理化性质，抗微生物和抗癌研究

摘要

按照简单的湿化学方法合成了释放羰基的席夫碱螯合物衍生的Fe（III）配合物。通过其XRD图谱和FTIR光谱证实了配合物中菱形的配体与金属离子的菱形堆积。通过UV-Vis。，PL，FTIR，XRD和TEM技术对化合物进行表征。通过琼脂圆盘扩散抗菌筛选，在革兰氏阳性和革兰氏阴性细菌上已阐明了该复合物的生物相容性优于纯席夫碱。该复合物在体外也显示出pH响应MTT分析显示，MCF-7乳腺癌细胞具有抗癌作用。CO和席夫碱的释放以及Fe（III）与细胞内线粒体的相互作用是细胞生物相容性的关键因素。这种CORM复合物对MCF-7细胞的抗癌活性高于席夫碱，因此可能成为未来生物医学应用的潜在候选物。

图形摘要

合成了新的Fe（III）的羰基释放CORM-席夫碱配合物。这种释放CO的复合物在水中呈25 ppm浓度时表现出菱形堆积，八面体几何形状并表现出抗菌活性。该复合物具有良好的抗微生物-抗癌潜力。