The review summarizes the data on the role of metabolic and repair systems in the mechanisms of therapy-related carcinogenesis and the effect of their polymorphism on the cancer development risk. The carcinogenic activity of different types of drugs, from the anticancer agents to analgesics, antipyretics, immunomodulators, hormones, natural remedies, and non-cancer drugs, is described. Possible approaches for the prevention of drug-related cancer induction at the initiation and promotion stages are discussed.

中文翻译：

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药物相关致癌作用：危险因素和预防方法

该综述总结了代谢和修复系统在治疗相关致癌机制中的作用及其多态性对癌症发展风险的影响的数据。描述了不同类型药物的致癌活性，从抗癌药到镇痛药、解热药、免疫调节剂、激素、自然疗法和非癌症药物。讨论了在启动和推广阶段预防药物相关癌症诱发的可能方法。