Background

Periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome is a cyclic autoinflammatory disease generally diagnosed in childhood. There have been studies suggesting a relationship between menstruation and other autoinflammatory syndromes such as familial Mediterranean fever (FMF), but not PFAPA specifically.

Case

This case describes a patient with a diagnosis of PFAPA who experienced complete resolution with tonsillectomy only to have recurrence of symptoms with onset of menstruation. She experienced symptom control with initiation of oral contraceptives.

Summary and Conclusion

Prior to this case report, there had been no evidence in the literature suggesting a relationship between PFAPA and menstruation despite the observed association in other autoinflammatory syndromes. Onset of menses may be a trigger in PFAPA.

中文翻译：

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有周期性发烧史的患者与月经相关的症状复发。

 背景

周期性发热、口疮性口炎、咽炎、腺炎 (PFAPA) 综合征是一种周期性自身炎症性疾病，通常在儿童时期诊断。有研究表明月经与家族性地中海热 (FMF) 等其他自身炎症综合征之间存在关联，但与 PFAPA 无关。

 案件

该病例描述了一名被诊断为 PFAPA 的患者，通过扁桃体切除术完全缓解，但随着月经来潮症状又复发。通过开始服用口服避孕药，她的症状得到了控制。

 总结与结论

在本病例报告之前，文献中没有证据表明 PFAPA 与月经之间存在关系，尽管在其他自身炎症综合征中观察到了相关性。月经来潮可能是 PFAPA 的触发因素。