HLA-G is a nonclassical MHC-Class I molecule whose expression, along the feto-maternal barrier contributes towards tolerance of the semiallogeneic fetus during pregnancy. In light of its inhibitory properties, recent research has established HLA-G involvement in mechanisms responsible for directing allogeneic immune responses towards tolerance during allogeneic situations such as organ transplantation. Here, we critically review the data supporting the tolerogenic role of HLA-G in organ transplantation, the various factors influencing its expression, and the introduction of novel humanized mouse models that are one of the best approaches to assess the utility of HLA-G as a therapeutic tool in organ transplantation.

HLA-G 是一种非经典的 MHC-I 类分子，其沿着胎儿-母体屏障的表达有助于在怀孕期间对半同种异体胎儿的耐受性。鉴于其抑制特性，最近的研究已经确定 HLA-G 参与负责在同种异体情况下（如器官移植）将同种异体免疫反应导向耐受的机制。在这里，我们批判性地审查了支持 HLA-G 在器官移植中的致耐受作用的数据、影响其表达的各种因素，以及新的人源化小鼠模型的引入，这些模型是评估 HLA-G 效用的最佳方法之一器官移植的治疗工具。