This manuscript is a continuation of this laboratory’s journey to identifying novel HLA alleles while performing routine clinical HLA laboratory testing. Since our last paper, we have identified an additional 28 novel HLA alleles that are identified and described herein. One novel allele was found in two unrelated patients that were HLA typed for different reasons at two different times, suggesting that novel alleles may be much more frequent than previously expected. If the rate of identification is hindered by bioinformatics challenges, there is a great potential for our patients to suffer needlessly from incomplete information in either diagnostics or unrecognized incompatibilities with potential donors.

该手稿是该实验室在执行常规临床HLA实验室测试时识别新HLA等位基因的过程的延续。自上篇论文发表以来，我们已经鉴定了另外28个在本文中鉴定和描述的HLA等位基因。在两名不相关的患者中，在两个不同的时间因不同的原因分型为HLA，发现了一个新的等位基因，这表明新的等位基因可能比以前预期的频率更高。如果鉴定率受到生物信息学挑战的阻碍，则我们的患者很有可能不必要地遭受诊断中信息不完整或潜在供体无法识别的不兼容性的困扰。