In this study, we investigated the effect of pap2 on colistin susceptibility using intact pap2 and truncated pap2 (pap2∆351) genes, which were found along with mcr-1 in plasmid. Our experiments based on conjugation, antibiotic susceptibility testing, and time-killing assay showed that an intact pap2 gene is necessary along with mcr-1 for reduced colistin susceptibility.

中文翻译：

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大肠菌素抗性似乎需要完整的mcr-1下游的pap2

在这项研究中，我们使用完整的pap2和截短的pap2（pap2Δ351）基因，以及质粒中的mcr-1，研究了pap2对粘菌素敏感性的影响。我们基于缀合，抗生素敏感性测试和杀灭时间的实验表明，完整的pap2基因与mcr-1一起对于降低大肠菌素敏感性很有必要。