The purpose of this study was to evaluate the clinical significance of fungi and multidrug-resistant organisms (MDROs) isolated from patients with intra-abdominal infections (IAIs). This multicenter study included consecutive patients admitted for microbiologically proven IAIs at 6 university-affiliated hospitals in South Korea between 2016 and 2018.

A total of 1571 patients were enrolled. Multivariable logistic regression analysis revealed that the isolation of MDROs, isolation of Candida spp., underlying renal diseases, Charlson comorbidity score ≥ 3, septic shock, failure to receive a required surgery or invasive intervention, secondary bacteremia due to IAIs, and lower body mass index were found to be independent predictors for 28-day mortality. However, the isolation of Enterococcus spp. was not identified as a significant risk factor. MDROs and Candida spp. were found in 42 (2.7%) and 395 (25.1%), patients respectively. The isolation of MDROs or Candida spp. was a surrogate marker of 28-day mortality.

本研究的目的是评估从腹腔内感染 (IAI) 患者中分离出的真菌和多重耐药菌 (MDRO) 的临床意义。这项多中心研究包括 2016 年至 2018 年在韩国 6 家大学附属医院接受微生物学证明 IAI 的连续患者。

共招募了 1571 名患者。多变量逻辑回归分析显示，MDROs 的分离、念珠菌属的分离、基础肾脏疾病、Charlson 合并症评分 ≥ 3、感染性休克、未能接受必要的手术或侵入性干预、IAI 引起的继发性菌血症和较低的体重指数被发现是 28 天死亡率的独立预测因子。然而，肠球菌属的分离。未被确定为重要的危险因素。MDRO 和念珠菌属。分别在 42 (2.7%) 和 395 (25.1%) 名患者中发现。MDROs 或念珠菌属的分离。是 28 天死亡率的替代标志物。