In this study, the utility and diagnostic accuracy of alkaline phosphatase on the surface membrane of neutrophils (mNAP) for bacteremia in patients with systemic inflammatory response syndrome (SIRS) was investigated and assessed. A total of 149 patients with SIRS were included. mNAP values were significantly higher in bacteremic SIRS group compared with that in non-bacteremic SIRS group (P< 0.001). The mNAP levels were significantly higher in SIRS patients with gram-negative bacteremia than those with gram-positive bacteremia. (P<0.001). The receiver operating characteristic (ROC) curve analysis revealed the areas under ROC (AUC) of 0.806 for mNAP in differentiating SIRS patients with bacteremia from those without, similar to that for procalcitonin (PCT) (0.797). Combination of PCT and mNAP gave an AUC of 0.841. mNAP shares a similar diagnostic accuracy to PCT in predicting bacteremia in SIRS patients. The combination of mNAP and PCT provides a better prediction of bacteremia in patients with SIRS than either test alone.

在这项研究中，研究和评估了嗜中性粒细胞表面膜上的碱性磷酸酶 (mNAP) 对全身炎症反应综合征 (SIRS) 患者菌血症的效用和诊断准确性。共纳入 149 名 SIRS 患者。菌血症SIRS组mNAP值显着高于非菌血症SIRS组（P<0.001）。具有革兰氏阴性菌血症的 SIRS 患者的 mNAP 水平显着高于革兰氏阳性菌血症的患者。(P<0.001)。受试者工作特征 (ROC) 曲线分析显示，mNAP 在区分有菌血症的 SIRS 患者与无菌血症的 SIRS 患者方面的 ROC (AUC) 下面积为 0.806，类似于降钙素原 (PCT) (0.797)。PCT 和 mNAP 的组合产生 0.841 的 AUC。mNAP 在预测 SIRS 患者的菌血症方面与 PCT 具有相似的诊断准确性。mNAP 和 PCT 的组合比单独的任何一种测试都能更好地预测 SIRS 患者的菌血症。