A biologically - validated biodegradable material must comfortably stay in the physiological environment it is placed in, before finally disappearing over the intended period of time with adequate rates of degradation. The primary objective and utility of such a material is to eliminate the requirement of secondary surgery in applications involving bone implants. In recent decades, biodegradable alloys have exhibited enhanced biocompatibility, and improved mechanical and biodegradation properties. This has generated renewed interest in the design of bone implants made up of such materials that can successfully support fractured bone till the culmination of the healing process. However, striking a balance between two seemingly conflicting requirements, namely - sustaining the strength of the implant till the bone acquires the desired strength of its own, and allowing the implant to keep losing strength with its gradual degradation – may be rather complex. To manage this, different healing phases and the associated bone - biodegradable implant interface mechanobiology needs to be focused upon. An adequate and/or optimal design of the implant is based on mechanical properties, degradation rates of implant and bone-biodegradable implant interface interactivity. This review mainly focuses on bone - biodegradable implant interface with due consideration accorded to the mechanical properties, degradation rates and healing process in a standard duration.

经过生物验证的可生物降解材料必须舒适地留在其所处的生理环境中，然后才能在预期的时间段内以适当的降解速率最终消失。这种材料的主要目的和用途是消除涉及骨植入物的应用中的二次手术。在最近的几十年中，可生物降解的合金表现出增强的生物相容性以及改善的机械和生物降解性能。这使人们对由这种材料制成的骨植入物的设计产生了新的兴趣，这种材料可以成功地支撑骨折的骨直到愈合过程达到顶点。但是，要在两个看似矛盾的要求之间取得平衡，即-维持植入物的强度，直到骨骼获得所需的自身强度，并允许植入物随着其逐渐退化而失去强度-可能会非常复杂。为了解决这个问题，需要关注不同的愈合阶段以及相关的骨骼-可生物降解的植入物界面力学生物学。植入物的适当和/或最佳设计基于机械性能，植入物的降解率和骨可生物降解的植入物界面相互作用。这项审查主要侧重于骨骼-可生物降解的植入物界面，并在标准时间内适当考虑了机械性能，降解速率和愈合过程。不同的愈合阶段以及相关的骨骼-可生物降解的植入物界面力学生物学需要重点关注。植入物的适当和/或最佳设计基于机械性能，植入物的降解率和骨可生物降解的植入物界面相互作用。这篇综述主要关注骨骼-可生物降解的植入物界面，并适当考虑了标准时间内的机械性能，降解速率和愈合过程。不同的愈合阶段以及相关的骨骼-可生物降解的植入物界面力学生物学需要重点关注。植入物的适当和/或最佳设计基于机械性能，植入物的降解率和骨可生物降解的植入物界面相互作用。这项审查主要侧重于骨骼-可生物降解的植入物界面，并在标准时间内适当考虑了机械性能，降解速率和愈合过程。