Objective

This paper is to examine the relationship between serum soluble programmed death ligand 1(sPD-L1) levels and the development of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA).

Method

Serum sPD-L1 were measured by enzyme-linked immunosorbent assay. sPD-L1 levels in RA with ILD, RA without ILD and healthy controls were compared. Associations between ILD and various markers including sPD-L1 and confounding factors were investigated by logistic regression analysis. Diagnostic values of sPD-L1 for the presence of ILD were investigated using receiver operating characteristics curve analysis.

Results

Serum sPD-L1 levels were higher in RA patients with ILD than RA patients without ILD and healthy controls (23.7 ± 9.8 vs. 18.0 ± 7.7 pg/mL, P = 0.01 and 23.7 ± 9.8 vs. 2.9 ± 1.5 pg/mL, P < 0.0001). sPD-L1 levels were positively correlated with RF titer (r = 0.245, P = 0.03), CRP (r = 0.265,P = 0.01), HRCT score (r = 0.265, P = 0.04) and Ferritin (r = 0.442, P = 0.01), but negatively associated with FVC% (r = −0.359, P = 0.01) and DLCO% (r = −0.399, P = 0.008). sPD-L1 and anti-CCP antibody status were independently associated with the presence of ILD during multivariate logistic regression analysis. Sensitivity and specificity of sPD-L1 levels for the detection of ILD in RA patients were 51.7% and 79.3%, respectively (area under the curve = 0.661).

Conclusion

Serum sPD-L1 levels were increased in RA patients with ILD. Increased sPD-L1 levels were associated with the presence of ILD.

中文翻译：

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血清可溶性程序性死亡配体1（sPD-L1）增加与类风湿关节炎间质性肺疾病的存在有关：单中心横断面研究。

目的

本文旨在探讨类风湿关节炎（RA）患者血清可溶性程序性死亡配体1（sPD-L1）水平与间质性肺疾病（ILD）的发展之间的关系。

方法

通过酶联免疫吸附测定法测定血清sPD-L1。比较有ILD的RA，无ILD的RA和健康对照组的sPD-L1水平。通过逻辑回归分析研究了ILD与各种标志物（包括sPD-L1和混杂因素）之间的关联。使用接收器工作特性曲线分析研究了sPD-L1对ILD的诊断价值。

结果

有ILD的RA患者的血清sPD-L1水平高于没有ILD和健康对照组的RA患者（23.7±9.8 vs. 18.0±7.7 pg / mL，P  = 0.01和23.7±9.8 vs. 2.9±1.5 pg / mL，P  <0.0001）。sPD-L1水平与RF滴度（r = 0.245，P  = 0.03），CRP（r = 0.265，P  = 0.01），HRCT评分（r = 0.265，P  = 0.04）和铁蛋白（r = 0.442，P）正相关。  = 0.01），但与FVC％（r = -0.359，P  = 0.01）和DLCO％（r = -0.399，P = 0.008）。在多因素logistic回归分析中，sPD-L1和抗CCP抗体的状态与ILD的存在独立相关。sPD-L1水平在RA患者中检测ILD的敏感性和特异性分别为51.7％和79.3％（曲线下面积= 0.661）。

结论

患有ILD的RA患者的血清sPD-L1水平升高。sPD-L1水平升高与ILD的存在有关。