Transbronchial lung cryobiopsy (TBLC) is an emerging technique for the diagnosis of interstitial lung disease (ILD), but its risk benefit ratio has been questioned. The objectives of this research were to describe any adverse events that occur within 90 days following TBLC and to identify clinical predictors that could help to detect the population at risk.

Methods

We conducted an ambispective study including all patients with suspected ILD who underwent TBLC. Data were collected concerning the safety profile of this procedure and compared to various clinical variables.

Results

Overall, 257 TBLCs were analysed. Complications were observed in 15.2% of patients; nonetheless, only 5.4% of all patients required hospital admission on the day of the procedure. In the 30 and 90 days following the TBLC, rates of readmission were 1.3% and 3.5% and of mortality were 0.38%, and 0.78% respectively. Two models were built to predict early admission (AUC 0.72; 95% CI 0.59–0.84) and overall admission (AUC 0.76; 95% CI 0.67–0.85).

Conclusions

Within 90 days after TBLC, 8.9% of patients suffered a complication serious enough to warrant hospital admission. Modified MRC dyspnoea score ≥2, FVC<50%, and a Charlson Comorbidity Index score ≥2 were factors that predicted early and overall admission.

中文翻译：

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间质性肺疾病进行肺冰冻活检后的90天内出现并发症和入院。

经支气管肺冷冻检查（TBLC）是一种诊断间质性肺疾病（ILD）的新兴技术，但其风险获益率一直受到质疑。这项研究的目的是描述TBLC发生后90天内发生的任何不良事件，并确定可以帮助发现高危人群的临床预测指标。

方法

我们进行了一项前瞻性研究，包括所有接受TBLC的可疑ILD患者。收集有关该程序安全性的数据，并与各种临床变量进行比较。

结果

总共分析了257个TBLC。15.2％的患者出现并发症；尽管如此，在手术当天只有5.4％的患者需要住院。TBLC后的30天和90天，再次入院率分别为1.3％和3.5％，死亡率分别为0.38％和0.78％。建立了两个模型来预测早期入院（AUC 0.72； 95％CI 0.59-0.84）和整体入院（AUC 0.76; 95％CI 0.67-0.85）。

结论

TBLC后90天内，有8.9％的患者发生严重并发症以至于需要住院。改良的MRC呼吸困难评分≥2，FVC <50％和查尔森合并症评分≥2是预测早期和整体入院的因素。