Endocrine disruption continues to be a matter of high concern, and a subject of intensive activities at the public, political, regulatory and academic levels. Currently, available regulatory test guidelines (TGs) relevant to the identification of endocrine disrupters are largely limited to estrogen, androgen, thyroid and steroidogenesis (EATS) pathways. Thus, there is an increasing interest and need to develop test methods, biomarkers, and Adverse Outcome Pathways (AOPs), for identification and evaluation of endocrine disrupters in addition to the EATS pathways. An activity focusing on the retinoid system has been jointly initiated by the Swedish Chemicals Agency and the European Commission. The retinoid system is involved in fundamental life processes and has been described, in previous work at the OECD, as a system susceptible to environmental endocrine disruption, the disruption of which could contribute to the increasing incidence of certain disorders in humans and wildlife populations.

内分泌干​​扰仍然是一个高度关注的问题，也是公众、政治、监管和学术层面密集活动的主题。目前，与内分泌干扰物鉴定相关的现有监管测试指南（TG）主要限于雌激素、雄激素、甲状腺和类固醇生成（EATS）途径。因此，人们越来越感兴趣并需要开发测试方法、生物标志物和不良结果途径 (AOP)，以鉴定和评估除 EATS 途径之外的内分泌干扰物。瑞典化学品管理局和欧盟委员会联合发起了一项针对类维生素A系统的活动。类维生素A系统涉及基本的生命过程，在经合组织之前的工作中已被描述为一种容易受到环境内分泌干扰的系统，其干扰可能导致人类和野生动物种群中某些疾病的发病率增加。