Immuno-hematologic parameters following rodent spinal cord contusion are negatively influenced by high-fat diet consumption,Journal of Neuroimmunology

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Immuno-hematologic parameters following rodent spinal cord contusion are negatively influenced by high-fat diet consumption
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.jneuroim.2020.577226
Jon M Person ₁ , Bradley A Welch ₂ , Redin A Spann ₂ , Kwamie K Harris ₂ , Yilianys Pride ₂ , Michelle A Tucci ₃ , Erin B Taylor ₄ , Bernadette E Grayson ₅

Affiliation

Spinal cord injury (SCI) results in perturbations to the immune system leading to increased infection susceptibility. In parallel, the consumption of high-fat diets (HFD) leads to a chronic inflammation in circulation and body tissues. We investigated the impact of 16 weeks of HFD on chronically-injured rats. SCI rats under both chow and HFD showed peripheral leukocyte changes that include reduced percentages of total, helper and cytotoxic T, and natural killer cells. Expression of immune-related genes in the spleen and thymus reflected the impact of both chronic injury and diet. Changes to the immune system following SCI are adversely impacted by HFD consumption.

中文翻译：

啮齿动物脊髓挫伤后的免疫血液学参数受到高脂肪饮食消耗的负面影响

脊髓损伤 (SCI) 导致免疫系统紊乱，导致感染易感性增加。与此同时，高脂肪饮食 (HFD) 的消耗会导致循环和身体组织的慢性炎症。我们调查了 16 周的 HFD 对慢性受伤大鼠的影响。Chow 和 HFD 下的 SCI 大鼠显示出外周白细胞变化，包括总、辅助和细胞毒性 T 细胞和自然杀伤细胞的百分比降低。脾脏和胸腺中免疫相关基因的表达反映了慢性损伤和饮食的影响。SCI 后免疫系统的变化受到 HFD 消耗的不利影响。

更新日期：2020-06-01

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