BACKGROUND Pancreatic polypeptide (PP) hormone is a 36-amino-acid peptide released from the pancreas, the serum levels of which have been shown to rise upon food intake. The underlying mechanism for metabolic surgery in the treatment of patients with type 2 diabetes mellitus (T2DM) remains intriguing. We compared post-oral glucose challenge PP levels between patients undergoing laparoscopic gastric bypass (GB) and sleeve gastrectomy (SG) at 1 year after surgery. METHODS This hospital-based, prospective study followed up a total of 12 laparoscopic GB and 12 laparoscopic SG patients and evaluated their glucose homeostasis. One year after metabolic surgery, 75-g oral glucose tolerance tests (OGTTs) were performed in the patients in the GB and SG groups and the blood levels of PP were evaluated. RESULTS The laparoscopic GB group had stable serum PP levels within 120 min after OGTT; however, the levels were significantly higher in the laparoscopic SG group at 30 min after OGTT. The patients with complete T2DM remission did not exhibit significantly different PP levels at fasting and post-OGTT than those in patients without remission after GB. Similarly, after SG, patients with T2DM remission did not show significantly different PP levels at fasting and post-OGTT than those in patients without T2DM remission. CONCLUSIONS No significant difference was found in plasma PP levels after OGTT in T2DM patients that received either GB or SG, or in T2DM remitters or non-remitters 1 year after metabolic surgery.

中文翻译：

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代谢手术后口服葡萄糖攻击后胰多肽激素水平的变化：胃绕道术和袖状胃切除术的比较

背景胰腺多肽（PP）激素是一种从胰腺释放的 36 个氨基酸的肽，其血清水平已显示在食物摄入后升高。代谢手术治疗 2 型糖尿病 (T2DM) 患者的潜在机制仍然很有趣。我们比较了术后 1 年接受腹腔镜胃旁路术 (GB) 和袖状胃切除术 (SG) 的患者口服葡萄糖激发后 PP 水平。方法这项基于医院的前瞻性研究共随访了 12 名腹腔镜 GB 和 12 名腹腔镜 SG 患者，并评估了他们的葡萄糖稳态。代谢手术后1年，对GB和SG组患者进行75g口服葡萄糖耐量试验（OGTTs）并评估血PP水平。结果腹腔镜GB组OGTT后120 min内血清PP水平稳定；然而，在 OGTT 后 30 分钟，腹腔镜 SG 组的水平显着更高。T2DM 完全缓解的患者在禁食和 OGTT 后的 PP 水平与 GB 后未缓解的患者相比没有显着差异。同样，在 SG 后，T2DM 缓解的患者在禁食和 OGTT 后的 PP 水平与 T2DM 未缓解的患者相比没有显着差异。结论 在接受 GB 或 SG 治疗的 T2DM 患者中，或在代谢手术后 1 年的 T2DM 缓解者或非缓解者中，OGTT 后血浆 PP 水平没有发现显着差异。与GB后未缓解的患者相比，T2DM完全缓解的患者在禁食和OGTT后的PP水平没有显着差异。同样，在 SG 后，T2DM 缓解的患者在禁食和 OGTT 后的 PP 水平与 T2DM 未缓解的患者相比没有显着差异。结论 在接受 GB 或 SG 治疗的 T2DM 患者中，或在代谢手术后 1 年的 T2DM 缓解者或非缓解者中，OGTT 后血浆 PP 水平没有发现显着差异。与GB后未缓解的患者相比，T2DM完全缓解的患者在禁食和OGTT后的PP水平没有显着差异。同样，在 SG 后，T2DM 缓解的患者在禁食和 OGTT 后的 PP 水平与 T2DM 未缓解的患者相比没有显着差异。结论 在接受 GB 或 SG 治疗的 T2DM 患者中，或在代谢手术后 1 年的 T2DM 缓解者或非缓解者中，OGTT 后血浆 PP 水平没有发现显着差异。