当前位置: X-MOL 学术J. Microbiol. Immunol. Infect. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Effects of lactoferrin on infectious diseases in Japanese summer: A randomized, double-blinded, placebo-controlled trial
Journal of Microbiology, Immunology and Infection ( IF 4.5 ) Pub Date : 2020-02-26 , DOI: 10.1016/j.jmii.2020.02.010
Hirotsugu Oda 1 , Hiroyuki Wakabayashi 1 , Miyuki Tanaka 1 , Koji Yamauchi 1 , Chihiro Sugita 2 , Hiroki Yoshida 2 , Fumiaki Abe 1 , Tohru Sonoda 3 , Masahiko Kurokawa 2
Affiliation  

Purpose

To investigate the effects of lactoferrin (LF) on infectious diseases in Japanese summer.

Methods

An intake of placebo, 200 mg, or 600 mg of LF were administered to healthy adults in Kyushu University of Health and Welfare for 12 weeks in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The primary endpoints were the prevalence and duration of infectious diseases and changes in immune parameters.

Results

Three hundred and ten subjects were randomized (placebo, n = 104; 200 mg, n = 103; 600 mg, n = 103). Twenty subjects were lost to the follow-up, leaving 290 for a full analysis set (n = 99; n = 95; n = 96). The duration (day) of total infectious diseases was shorter in the 200 mg group (2.0, p = 0.045) and 600 mg group (2.0, p = 0.010) than in the placebo group (3.0). The duration of summer colds was shorter in the 600 mg group (2.0, p = 0.036) than in the placebo group (3.0). No significant differences were observed in the prevalence of infectious diseases or changes in immune parameters. In exploratory investigations, changes in the neutrophil phagocytic capacity, cortisol concentrations, and T score of “Vigor/Activity” in the Profile of Mood States 2 were greater in the 600 mg group than in the placebo group, when analysis was done on the lower half groups at the baseline. Adverse events were similar in each group and none had a causal relationship with the intake of the test foods.

Conclusions

In summer, the intake of LF attenuates infectious diseases, including summer colds.



中文翻译:

乳铁蛋白对日本夏季传染病的影响:一项随机、双盲、安慰剂对照试验

目的

研究乳铁蛋白(LF)对日本夏季传染病的影响。

方法

在一项随机、双盲、安慰剂对照的平行组比较试验中,九州保健福利大学的健康成人服用安慰剂、200 毫克或 600 毫克 LF,持续 12 周。主要终点是传染病的流行和持续时间以及免疫参数的变化。

结果

三百一十名受试者被随机分配(安慰剂,n = 104;200 mg,n = 103;600 mg,n = 103)。20 名受试者失去了随访,剩下 290 名用于完整分析集(n = 99;n = 95;n = 96)。200 mg 组 (2.0, p = 0.045) 和 600 mg 组 (2.0, p = 0.010) 的总传染病持续时间 (天) 比安慰剂组 (3.0) 短。600 mg 组 (2.0, p = 0.036) 的夏季感冒持续时间比安慰剂组 (3.0) 短。在传染病的流行或免疫参数的变化方面没有观察到显着差异。在探索性研究中,600 毫克组的中性粒细胞吞噬能力、皮质醇浓度和情绪状态概况 2 中“活力/活动”的 T 评分的变化大于安慰剂组,当对基线的下半组进行分析时。各组的不良事件相似,且均与测试食物的摄入量没有因果关系。

结论

在夏季,摄入 LF 可以减轻传染病,包括夏季感冒。

更新日期:2020-02-26
down
wechat
bug