Highlights • Longitudinal magnetic resonance imaging identified increased total brain volume in older mdx mice.• Decreases in grey matter volume of mdx mouse hippocampus were noticeable from 12 months.• Mdx mice demonstrated deficits in hippocampal long-term spatial learning and memory.• Increased levels of anxiety-related behaviour shown by older mdx mice.

中文翻译：

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mdx 小鼠的认知障碍呈渐进性

亮点 • 纵向磁共振成像确定老年 mdx 小鼠的总脑容量增加。• mdx 小鼠海马的灰质体积从 12 个月开始明显减少。• Mdx 小鼠表现出海马长期空间学习和记忆的缺陷。• 水平增加老年 mdx 小鼠表现出的焦虑相关行为。