Leishmania are obligate intracellular parasites of mononuclear phagocytes transmitted by Phlebotomine sandflies. Monocytes are one of the main cell types recruited to the site of the bite having an important role in the defense against Leishmania parasites in the first hours of infection. In the tissue, macrophages play a pivotal role as both the primary replication sites and the major effector cells responsible for parasite elimination. Many authors have reviewed the monocyte/macrophage-Leishmania interactions from results derived in mice, however, given the important differences between mice an humans we considered vital to discuss the role of these cells in human leishmaniasis. In this review, we recapitulated the most important studies carried out to understand the different roles of human monocyte/macrophages in Leishmania infection and how they can participate in both control and the immunopathogenesis of the disease.

中文翻译：

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单核细胞/巨噬细胞在利什曼原虫感染中的作用：人类反应一目了然。

利什曼原虫是由竹毒mine传播的单核吞噬细胞的胞内寄生虫。单核细胞是募集到叮咬位点的主要细胞类型之一，在感染的最初几个小时内对抵抗利什曼原虫的寄生虫具有重要作用。在组织中，巨噬细胞作为主要的复制位点和负责寄生虫消除的主要效应细胞都起着关键作用。许多作者已经从小鼠获得的结果中回顾了单核细胞/巨噬细胞-利什曼原虫的相互作用，但是，鉴于小鼠与人类之间的重要差异，我们认为讨论这些细胞在人利什曼病中的作用至关重要。在这篇评论中