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The immunopathogenesis of tuberculous pericarditis.
Microbes and Infection ( IF 5.8 ) Pub Date : 2020-02-21 , DOI: 10.1016/j.micinf.2020.02.001
Patrick Howlett 1 , Elsa Du Bruyn 2 , Hazel Morrison 3 , Isiguzo C Godsent 4 , Katalin A Wilkinson 5 , Mpiko Ntsekhe 2 , Robert J Wilkinson 6
Affiliation  

Tuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8 and 34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940–50s. This review summarises recent advances in the histology, microbiology and immunology of tuberculous pericarditis, with special focus on the effect of Human Immunodeficiency Virus (HIV) and the determinants of constriction.



中文翻译:

结核性心包炎的免疫发病机制。

结核性心包炎是肺外结核的一种严重形式,在高发情况下是心包积液的最常见原因。死亡率在8%到34%之间,是非洲和亚洲心包收缩的主要原因。当前对该疾病的了解是基于1940-50年代进行的研究得出的模型。这篇综述总结了结核性心包炎的组织学,微生物学和免疫学方面的最新进展,特别关注了人类免疫缺陷病毒(HIV)的作用和收缩的决定因素。

更新日期:2020-02-21
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