OBJECTIVE To investigate whether strength or aerobic training can offer significantly more benefits with regards to the activities of daily living of elderly patients with dementia, as well as to determine the effects of exercise on cognition, depression, and biochemical markers. DESIGN Single-blind randomized controlled trial SETTING: A nursing home for veterans PARTICIPANTS: A volunteer sample of 80 participants whose scores on the Mini-Mental State Examination were between 15 and 26 were included. Due to cardiopulmonary or orthopedic conditions which prohibit exercise training, along with any cognitive problems that may impede answering the contents of our questionnaires, 11 participants were excluded. During the exercise training period, 8 participants voluntarily dropped out of the study. INTERVENTIONS The participants were randomly assigned to perform either strength or aerobic training for a total of four weeks. OUTCOME MEASURES The main outcome measure was the Barthel Index. Other outcome measures included the Mini-Mental State Examination, Montreal Cognitive Assessment, Geriatric Depression Scale, plasma monocyte chemotactic protein-1 levels, insulin-like growth factor-1 levels, and serum brain-derived neurotrophic factor levels. RESULTS After completion of the program, we discovered a significant improvement in the patients' Barthel Index, Mini-Mental State Examination, Montreal Cognitive Assessment, and plasma monocyte chemotactic protein-1 levels in the strength-training group. For the patients who had received aerobic training, their serum brain-derived neurotrophic factor also improved significantly. However, the degree of improvement regarding these outcome measures did not achieve significant statistical difference between the two groups. CONCLUSION Through our study, an intensive four-week exercise program, whether it be strength or aerobic training, is evidenced to bring significant benefits to elderly patients with dementia, while the serum brain-derived neurotrophic factor was additionally improved through aerobic training.

中文翻译：

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运动训练对老年痴呆症的治疗效果：一项随机对照试验

目的 调查力量训练或有氧训练是否可以为老年痴呆症患者的日常生活活动提供更多益处，并确定运动对认知、抑郁和生化指标的影响。设计 单盲随机对照试验 设置：退伍军人疗养院 参与者：包括 80 名参与者的志愿者样本，他们的简易精神状态检查得分在 15 到 26 之间。由于心肺或骨科疾病禁止运动训练，以及任何可能妨碍回答我们问卷内容的认知问题，11 名参与者被排除在外。在运动训练期间，8名参与者自愿退出研究。干预 参与者被随机分配进行总共四个星期的力量或有氧训练。结果测量 主要的结果测量是 Barthel 指数。其他结果测量包括简易精神状态检查、蒙特利尔认知评估、老年抑郁量表、血浆单核细胞趋化蛋白 1 水平、胰岛素样生长因子 1 水平和血清脑源性神经营养因子水平。结果 完成该计划后，我们发现力量训练组患者的 Barthel 指数、简易精神状态检查、蒙特利尔认知评估和血浆单核细胞趋化蛋白 1 水平有显着改善。接受有氧训练的患者，其血清脑源性神经营养因子也有明显改善。然而，这些结果指标的改善程度在两组之间没有达到显着的统计学差异。结论通过我们的研究，无论是力量训练还是有氧训练，为期4周的强化锻炼计划对老年痴呆症患者带来显着益处，同时通过有氧训练进一步提高血清脑源性神经营养因子。