OBJECTIVE To summarize the literature on definitions, assessment protocols and outcome measures for motor fatigability in neurological patients and investigates the known clinimetric properties according to the COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN) criteria. DATA SOURCES Two databases were consulted for studies published between 01/2003 and 11/2018 using the terms 'motor fatigability','nervous system disease' and 'upper limb'. STUDY SELECTION Studies were included if they were (1) not older than 15 years, (2) written in English, German or Dutch, (3) involved upper limbs of neurological patients, (4) adequately described protocols using maximum voluntary contractions. DATA EXTRACTION Thirty-three studies were included, describing 14 definitions, 37 assessment protocols and 9 outcome measures. The following data was obtained: (1) author, publication year, (2) aim, (3) fatigability definition, (4) sample characteristics, (5) fatigability protocol, (8) measurement system, and (9) outcome measure. DATA SYNTHESIS Protocols relating to Body Function level of the International Classification of Functioning (ICF) were most often performed in patients with multiple sclerosis (MS) including maximal/submaximal, isometric/concentric and eccentric contractions of variable duration. For ICF Activities level, most protocols included wheelchair-related tasks. Clinimetric properties were known in two included protocols. Test-retest reliability in MS patients were moderate to excellent for the Static Fatigue Index and moderate for the Dynamic Fatigue Index. CONCLUSIONS Based on physiology, recommendations are made for protocols and outcome measures for motor fatigability at the ICF Body Function level. For the ICF Activities level, too little is known to make sound statements on the use of protocols in neurological populations. Clinimetric properties should be further investigated for neurological populations.

中文翻译：

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测量神经系统疾病患者上肢的运动疲劳。系统评价

目的 总结关于神经系统患者运动疲劳的定义、评估方案和结果测量的文献，并根据基于共识的健康状态测量仪器选择标准 (COSMIN) 研究已知的临床特性。数据来源 在 2003 年 1 月 1 日至 2018 年 11 月期间发表的研究中，使用了“运动易疲劳性”、“神经系统疾病”和“上肢”等术语，查阅了两个数据库。研究选择 纳入以下条件的研究：(1) 不超过 15 岁，(2) 用英语、德语或荷兰语书写，(3) 涉及神经系统患者的上肢，(4) 充分描述了使用最大自主收缩的方案。数据提取 纳入了 33 项研究，描述了 14 个定义，37 项评估方案和 9 项结果措施。获得了以下数据：(1) 作者、出版年份、(2) 目标、(3) 易疲劳性定义、(4) 样本特征、(5) 易疲劳性方案、(8) 测量系统和 (9) 结果测量。数据综合 与国际功能分类 (ICF) 的身体功能水平相关的协议最常用于多发性硬化症 (MS) 患者，包括最大/次最大、等长/同心和不定持续时间的离心收缩。对于 ICF 活动级别，大多数协议包括与轮椅相关的任务。在两个包含的协议中已知临床特性。MS 患者的重测信度在静态疲劳指数方面为中等至极好，在动态疲劳指数方面为中等。结论 基于生理学，对 ICF 身体功能水平的运动疲劳性的方案和结果测量提出了建议。对于 ICF 活动级别，对于神经病学人群中协议的使用，我们所知甚少。应进一步研究神经学群体的临床特性。