Thoughts on the evolution of Core Environmental Responses in yeasts,Fungal Biology

当前位置： X-MOL 学术 › Fungal Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Thoughts on the evolution of Core Environmental Responses in yeasts
Fungal Biology ( IF 2.9 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.funbio.2020.01.003
Alistair J P Brown ₁ , Daniel E Larcombe ₁ , Arnab Pradhan ₁

Affiliation

The model yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, display Core Environmental Responses (CERs) that include the induction of a core set of stress genes in response to diverse environmental stresses. CERs underlie the phenomenon of stress cross-protection, whereby exposure to one type of stress can provide protection against subsequent exposure to a second type of stress. CERs have probably arisen through the accumulation, over evolutionary time, of protective anticipatory responses (“adaptive prediction”). CERs have been observed in other evolutionarily divergent fungi but, interestingly, not in the pathogenic yeast, Candida albicans. We argue that this is because we have not looked in the right place. In response to specific host inputs, C. albicans does activate anticipatory responses that protect it against impending attack from the immune system. Therefore, we suggest that C. albicans has evolved a CER that reflects the environmental challenges it faces in host niches.

中文翻译：

关于酵母核心环境反应进化的思考

模型酵母、Saccharomyces cerevisiae 和 Schizosaccharomyces pombe 显示核心环境反应 (CER)，其中包括诱导一组核心应激基因以响应不同的环境压力。CER 是压力交叉保护现象的基础，因此暴露于一种压力可以提供保护，防止随后暴露于第二种压力。CER 可能是通过在进化时间内积累的保护性预期反应（“适应性预测”）产生的。已经在其他进化上不同的真菌中观察到 CER，但有趣的是，在致病酵母白色念珠菌中没有观察到。我们认为这是因为我们没有找对地方。响应特定主机输入，C. 白色念珠菌确实会激活预期反应，保护它免受免疫系统即将发生的攻击。因此，我们建议白色念珠菌已经进化出一种 CER，它反映了它在宿主生态位中面临的环境挑战。

更新日期：2020-05-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11