Using the same ultrasound detector, hybrid optoacoustic-ultrasound (OPUS) imaging provides concurrent scans of tissue slices or volumes and visualizes complementary sound- and light-based contrast at similar resolutions. In addition to the benefit of hybrid contrast, spatial co-registration enables images from one modality to be employed as prior information for improving an aspect of the performance of the other modality. We consider herein a handheld OPUS system and utilize structural information from ultrasound images to guide regional Laplacian regularization-based reconstruction of optoacoustic images. Using phantoms and data from OPUS scans of human radial and carotid arteries, we show that ultrasound-driven optoacoustic inversion reduces limited-view artefacts and improves image contrast. In phantoms, prior-integrated reconstruction leads to a 50 % higher contrast-to-noise ratio (CNR) of the image than standard reconstruction, and a 17 % higher structural similarity (SSIM) index. In clinical data, prior-integrated reconstruction detects deep-seated radial arteries with higher CNR than the standard method at three different depths. In this way, the prior-integrated method offers unique insights into atherosclerotic carotid plaques in humans (with p<0.01 between patients and healthy volunteers), potentially paving the way for new abilities in vascular imaging and more generally in optoacoustic imaging.

使用相同的超声波检测器，混合声光超声（OPUS）成像可同时扫描组织切片或体积，并以相似的分辨率可视化互补的基于声音和光的对比度。除了混合对比度的优点之外，空间共配准还可以将一种模态的图像用作先验信息，以改善另一种模态的性能。我们在这里考虑一种手持式OPUS系统，并利用超声图像中的结构信息来指导基于局部拉普拉斯正则化的光声图像重建。使用人体radial骨和颈动脉的OPUS扫描中的体模和数据，我们显示了超声驱动的光声反演可减少有限视野的伪像并改善图像对比度。在幻影中 与标准重建相比，先验集成重建可以使图像的对比度-噪声比（CNR）高出50％，而结构相似性（SSIM）指数也高出17％。在临床数据中，在三个不同深度处，先行整合重建可检测到深radial骨动脉，其CNR高于标准方法。通过这种方式，先前整合的方法为人类的动脉粥样硬化斑块提供了独特的见解（患者与健康志愿者之间的p <0.01），可能为血管成像乃至光声成像的新能力铺平了道路。先验整合重建在三个不同深度检测到深R骨动脉，其CNR比标准方法高。通过这种方式，先前整合的方法为人类的动脉粥样硬化斑块提供了独特的见解（患者与健康志愿者之间的p <0.01），可能为血管成像乃至光声成像的新能力铺平了道路。先验整合重建在三个不同深度检测到深R骨动脉，其CNR比标准方法高。通过这种方式，先前整合的方法为人类的动脉粥样硬化斑块提供了独特的见解（患者与健康志愿者之间的p <0.01），可能为血管成像乃至光声成像的新能力铺平了道路。