Polycystin-2 (PC2) is a calcium channel that can be found in the endoplasmic reticulum, the plasmatic membrane, and the primary cilium. The structure of PC2 is characterized by a highly ordered C-terminal tail with an EF-motif (calcium-binding domain) and a canonical coiled-coil domain (CCD; interaction domain), and its activity is regulated by interacting partners and post-translational modifications. Calcium mobilization into the cytosol by PC2 has been mainly associated with cell growth and differentiation, and therefore mutations or dysfunction of PC2 lead to renal and cardiac consequences. Interestingly, PC2-related pathologies are usually treated with rapamycin, an autophagy stimulator. Autophagy is an intracellular degradation process where recycling material is sequestered into autophagosomes and then hydrolyzed by fusion with a lysosome. Interestingly, several studies have provided evidence that PC2 may be required for autophagy, suggesting that PC2 maintains a physiologic catabolic state.

Polycystin-2（PC2）是一个钙通道，可以在内质网，质膜和初级纤毛中找到。PC2的结构特征是具有EF-基序（钙结合结构域）和规范的卷曲螺旋结构域（CCD；相互作用结构域）的高度有序的C末端尾部，其活性受相互作用伙伴和后结合体的调控。翻译修饰。钙被PC2动员到细胞质中主要与细胞生长和分化有关，因此PC2的突变或功能障碍会导致肾脏和心脏疾病。有趣的是，通常用雷帕霉素（一种自噬刺激物）治疗PC2相关的病理。自噬是一种细胞内降解过程，其中回收物质被螯合成自噬体，然后通过与溶酶体融合而水解。