The fate of a cell is determined by multiple signaling pathways in response to a range of stimuli. Probably the most prominent cell death mechanism is apoptosis which can be triggered by both internal stresses, as well as extracellular stimuli, and is executed by two well-characterized pathways, the intrinsic and the extrinsic apoptosis pathways. Although autophagy can also lead to cell death under certain circumstances, its major function is as a cell survival process. Given that the life of a cell is at stake, it is not surprising that there is significant molecular crosstalk between these pathways. The nature of these interconnections is diverse and ranges from protein-protein interactions and post-translational modifications through to the degradation of molecular components by different proteins and organelles. In this chapter we review these mechanisms in detail.

中文翻译：

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细胞凋亡和自噬信号通路之间的串扰。

细胞的命运是由响应一系列刺激的多种信号通路决定的。可能最突出的细胞死亡机制是细胞凋亡，它既可以由内在压力触发，也可以由细胞外刺激触发，并且可以通过两个特征明确的途径来执行，即内在和外在凋亡途径。尽管自噬在某些情况下也会导致细胞死亡，但其主要功能是作为细胞存活过程。考虑到细胞的生命受到威胁，这些途径之间存在明显的分子串扰也就不足为奇了。这些互连的性质是多种多样的，范围从蛋白质-蛋白质相互作用和翻译后修饰到不同蛋白质和细胞器对分子成分的降解。