Autophagy, the process of macromolecular degradation through the lysosome, has been extensively studied for the past decade or two. Autophagy can regulate cell death, especially apoptosis, through selective degradation of both positive and negative apoptosis regulators. However, multiple other programmed cell death pathways exist. As knowledge of these other types of cell death expand, it has been suggested that they also interact with autophagy. In this review, we discuss the molecular mechanisms that comprise three non-apoptotic forms of cell death (necroptosis, pyroptosis and ferroptosis) focusing on how the autophagy machinery regulates these different cell death mechanisms through (i) its degradative functions, i.e., true autophagy, and (ii) other non-degradative functions of the autophagy machinery such as serving as a signaling scaffold or by participating in other autophagy-independent cellular processes.

中文翻译：

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自噬和非凋亡细胞死亡途径之间的相互作用。

自噬是通过溶酶体降解大分子的过程，在过去的一两个世纪中已被广泛研究。自噬可以通过选择性降解正负凋亡调节因子来调节细胞死亡，尤其是凋亡。但是，存在多种其他程序性细胞死亡途径。随着对这些其他类型细胞死亡的了解的增加，已经表明它们也与自噬相互作用。在这篇综述中，我们讨论了包括三种非凋亡形式的细胞死亡（坏死病，发烧和铁生病）的分子机制，着重于自噬机制如何通过（i）其降解功能调节这些不同的细胞死亡机制，即真正的自噬，