Unicellular organisms like yeast can undergo controlled demise in a manner that is partly reminiscent of mammalian cell death. This is true at the levels of both mechanistic and functional conservation. Yeast offers the combination of unparalleled genetic amenability and a comparatively simple biology to understand both the regulation and evolution of cell death. In this minireview, we address the capacity of the nucleus as a regulatory hub during yeast regulated cell death (RCD), which is becoming an increasingly central question in yeast RCD research. In particular, we explore and critically discuss the available data on stressors and signals that specifically impinge on the nucleus. Moreover, we also analyze the current knowledge on nuclear factors as well as on transcriptional control and epigenetic events that orchestrate yeast RCD. Altogether we conclude that the functional significance of the nucleus for yeast RCD in undisputable, but that further exploration beyond correlative work is necessary to disentangle the role of nuclear events in the regulatory network.

中文翻译：

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酵母中受调节细胞死亡的转录和表观遗传控制。

像酵母这样的单细胞生物可以以部分让人想起哺乳动物细胞死亡的方式经历受控死亡。在机械和功能守恒的层面上都是如此。酵母提供了无与伦比的遗传适应性和相对简单的生物学相结合，以了解细胞死亡的调节和进化。在这篇小型综述中，我们讨论了在酵母调节细胞死亡 (RCD) 期间细胞核作为调节中心的能力，这正成为酵母 RCD 研究中越来越重要的问题。特别是，我们探索并批判性地讨论了有关特定影响细胞核的压力源和信号的可用数据。此外，我们还分析了当前关于核因子以及协调酵母 RCD 的转录控制和表观遗传事件的知识。