OBJECTIVE To investigate whether endometrial thickness (EMT) is associated with adverse obstetric and neonatal outcomes in fresh in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) cycles. DESIGN Retrospective cohort study. SETTING University-based reproductive medical center. PATIENT(S) Women under the age of 42 years who underwent IVF/ICSI treatment and received fresh ET in our unit from January 2017 to December 2018, resulting in a live singleton birth. INTERVENTION(S) Controlled ovarian hyperstimulation and IVF/ICSI; fresh ET. MAIN OUTCOME MEASURE(S) Birth weight, gestational age, small for gestational age (SGA), large for gestational age (LGA), placenta previa, placental abruption, hypertensive disorders, and gestational diabetes mellitus. RESULT(S) The risk of being born SGA was statistically significantly increased in the EMT ≤7.5 mm group compared with those from the EMT >12 mm group (adjusted odds ratio [aOR] 2.391; 95% confidence interval [CI], 1.155-4.950). Moreover, maternal body mass index, secondary infertility, preterm delivery, and hypertensive disorders were all independent predictors for SGA. The mean birth weights of singletons in women with EMT ≤7.5 mm were lower than in the groups with EMT >7.5-12 mm and EMT >12 mm (3.25 ± 0.56 kg vs. 3.38 ± 0.51 kg and 3.39 ± 0.53 kg, respectively). CONCLUSION(S) After fresh IVF/ICSI-ET, the risk of SGA was increased twofold in women with EMT ≤7.5 mm compared with women with EMT >12 mm. We suggest that women with a thin EMT after obtaining a pregnancy by IVF should receive improved prenatal care to reduce the risk of delivering a SGA infant.

中文翻译：

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子宫内膜厚度与新鲜体外受精-卵胞浆内单精子注射和胚胎移植周期中小于胎龄儿的发生率相关

目的 研究子宫内膜厚度 (EMT) 是否与新鲜体外受精/卵胞浆内单精子注射 - 胚胎移植 (IVF/ICSI-ET) 周期的不良产科和新生儿结局相关。设计 回顾性队列研究。设置 大学为基础的生殖医学中心。患者 2017 年 1 月至 2018 年 12 月在我们单位接受 IVF/ICSI 治疗并接受新鲜 ET 的 42 岁以下女性，导致活产单胎。干预（S）控制性卵巢过度刺激和 IVF/ICSI；新鲜的ET。主要观察指标 出生体重、胎龄、小于胎龄 (SGA)、大于胎龄 (LGA)、前置胎盘、胎盘早剥、高血压疾病和妊娠糖尿病。结果（S）与 EMT > 12 mm 组相比，EMT ≤ 7.5 mm 组出生 SGA 的风险在统计学上显着增加（调整优势比 [aOR] 2.391；95% 置信区间 [CI]，1.155- 4.950）。此外，孕妇体重指数、继发性不孕症、早产和高血压疾病都是 SGA 的独立预测因素。EMT ≤ 7.5 mm 女性的单胎平均出生体重低于 EMT >7.5-12 mm 和 EMT >12 mm 组（分别为 3.25 ± 0.56 kg 和 3.38 ± 0.51 kg 和 3.39 ± 0.53 kg） . 结论 (S) 新鲜 IVF/ICSI-ET 后，与 EMT > 12 mm 的女性相比，EMT ≤ 7.5 mm 的女性发生 SGA 的风险增加了两倍。