OBJECTIVE To evaluate the effects of gonadotropin-releasing hormone agonists (GnRH-a) on fertility in women with mild endometriosis who are undergoing in vitro fertilization and embryo transfer (IVF-ET) procedures. DESIGN Prospective, randomized, controlled trial. SETTING Three tertiary university hospitals. PATIENT(S) Four hundred infertile women with mild endometriosis, documented with laparoscopy, undergoing IVF and 200 women with tubal factor infertility. INTERVENTION(S) Administration of GnRH-a for 3 months before an IVF attempt (group A, n = 200) or IVF without GnRH-a (group B, n = 200). MAIN OUTCOME MEASURE(S) Follicular fluid (FF) levels of tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8, and IL-1 receptor antagonist; fertilization rate (FR), implantation rate (IR), quality of embryos, and clinical pregnancy rate (PR). RESULT(S) Women who received GnRH-a had a statistically significantly reduced concentration of FF cytokines compared with women who did not receive this regimen. Women in group B had a reduced FR (61.7; 95% CI, 59.20-64.20) compared with the women in group A (72.7; 95% CI, 70.50-74.90) and compared with the women with tubal factor infertility (74.7; 95% CI, 72.00-77.24). The embryo quality, IR, and clinical PR showed no statistically significant improvement in the women of group A compared with group B. CONCLUSION(S) Women who received GnRH-a for 3 months had a lower concentration of FF cytokines. These women had also a higher FR than the women who did not receive GnRH-a. However, the IR, embryo quality, and clinical PR showed no statistically significant difference when comparing the two groups. CLINICALTRIALS. GOV ID NCT01269125.

中文翻译：

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体外受精前超长服用促性腺激素释放激素激动剂可提高轻度子宫内膜异位症女性的受精率，但不能提高临床妊娠率：一项前瞻性、随机、对照试验

目的 评估促性腺激素释放激素激动剂 (GnRH-a) 对接受体外受精和胚胎移植 (IVF-ET) 手术的轻度子宫内膜异位症女性生育能力的影响。设计 前瞻性、随机、对照试验。设置 三所三级大学医院。患者 400 名患有轻度子宫内膜异位症的不孕妇女，经腹腔镜检查记录，接受试管婴儿和 200 名患有输卵管因素不孕症的妇女。干预措施 在尝试 IVF（A 组，n = 200）或不使用 GnRH-a 的 IVF（B 组，n = 200）之前使用 GnRH-a 3 个月。主要观察指标（S）肿瘤坏死因子α（TNF-α）、白介素-1β（IL-1β）、IL-6、IL-8和IL-1受体拮抗剂的滤泡液（FF）水平；受精率 (FR)、着床率 (IR)、胚胎质量和临床妊娠率 (PR)。结果 与未接受该方案的女性相比，接受 GnRH-a 的女性的 FF 细胞因子浓度在统计学上显着降低。与 A 组女性 (72.7；95% CI，70.50-74.90) 和输卵管因素不孕女性 (74.7；95) 相比，B 组女性的 FR (61.7；95% CI，59.20-64.20) 降低% CI，72.00-77.24）。与 B 组相比，A 组女性的胚胎质量、IR 和临床 PR 没有统计学上的显着改善。结论（S）接受 GnRH-a 治疗 3 个月的女性的 FF 细胞因子浓度较低。这些女性的 FR 也高于未接受 GnRH-a 的女性。然而，在比较两组时，IR、胚胎质量和临床PR没有显示出统计学上的显着差异。临床试验。政府编号 NCT01269125。