As a non-invasive technology, photodynamic therapy (PDT) has been widely studied for tumor ablation and infection control. In recent years, nanoparticle (NP)-based PDT has attracted significant interest in improving wound healing. By photodynamically tuning the temperature of the wounds, NP-based PDT may promote cell proliferation and generate reactive oxygen species, thereby playing a beneficial role in tissue regeneration. In this mini review, the recent pioneering work of NP-based PDT in enhancing wound healing of skin, bone, and cartilage is presented. Various types of light-to-heat and magnetic field-to-heat NPs with encouraging therapeutic effects on wound healing are detailed and compared. The PDT temperatures that can be used for wound healing are described. The pros and cons of NP-based PDT are summarized with special attention to the basic requirements of NPs to be used for wound healing treatments. Future research directions on how to decrease the non-specific interactions while increasing PDT efficiency are also discussed.

作为一种非侵入性技术，光动力疗法（PDT）已被广泛研究用于肿瘤消融和感染控制。近年来，基于纳米颗粒（NP）的PDT在改善伤口愈合方面引起了极大的兴趣。通过光动力调节伤口的温度，基于NP的PDT可以促进细胞增殖并生成活性氧，从而在组织再生中发挥有益作用。在这个小型综述中，介绍了基于NP的PDT在增强皮肤，骨骼和软骨伤口愈合方面的最新开创性工作。详细介绍并比较了各种类型的光热和磁场热NP，它们对伤口愈合具有令人鼓舞的治疗效果。描述了可用于伤口愈合的PDT温度。总结了基于NP的PDT的优缺点，并特别注意了用于伤口愈合治疗的NP的基本要求。还讨论了有关如何在提高PDT效率的同时减少非特异性相互作用的未来研究方向。