To develop multifunctional delivery systems of targeted properties for biomedical applications, hybrid fiber-nanoparticle matrices capable of controlled and monitored nanoparticles (NPs) delivery properties were prepared. Firstly, electropinning technique was applied to produce carbon nanotubes (CNTs) incorporated biodegradable poly(ϵ-caprolactone)/gelatin (PG) polymer fibers (PGC fibers). Subsequently, the photoluminescent mesoporous silica nanoparticles (PLMSNs) were electrostatically attached on the surface of PGC fibers to form a localized delivery platform. The PGC-PLMSNs fibers can emit red light under excitation at ~395 nm, 465 nm, and ~533 nm. Additionally, under NIR (808 nm) irradiation, PGC-PLMSNs fibers revealed good photothermal effect. PLMSNs loading efficiency onto the PGC fibers and PLMSNs release kinetics were assessed by TG method. More importantly, the 808 nm NIR irradiation enabled remarkably promoted PLMSNs release rate, validating the typical NIR-triggered release properties. Meanwhile, PLMSNs released from the composite fibers could be optically monitored by decrease in the intensity of red emission. These results suggest the possibility to develop the localized therapeutic device that may inspire other means of treatment method for cancer therapy.

为了开发针对生物医学应用的靶向特性的多功能递送系统，制备了能够控制和监控纳米颗粒（NPs）递送特性的混合纤维-纳米颗粒基质。首先，采用静电钉扎技术生产掺有可生物降解的聚（ε-己内酯）/明胶（PG）聚合物纤维（PGC纤维）的碳纳米管（CNT）。随后，将光致发光的中孔二氧化硅纳米粒子（PLMSN）静电附着在PGC纤维的表面上，以形成局部递送平台。PGC-PLMSNs光纤在〜395 nm，465 nm和〜533 nm的激发下可以发出红光。此外，在近红外（808 nm）照射下，PGC-PLMSNs纤维显示出良好的光热效应。通过TG法评估PLMSNs在PGC纤维上的负载效率和PLMSNs的释放动力学。更重要的是，808 nm NIR辐照能够显着提高PLMSNs的释放速率，从而验证了典型的NIR触发的释放特性。同时，可以通过减少红色发射强度来光学监测从复合纤维释放的PLMSN。这些结果表明开发局部治疗设备的可能性，该设备可以启发用于癌症治疗的其他治疗方法。