The delivery of drugs via fast dissolving films is an effective alternative for drugs with low bioavailability when administered by other routes. This is the case of domperidone (DMP) an anti-emetic drug with low water solubility and vulnerable to extensive first-pass effect. To overcome these limitations, in this work, we designed and produced fast dissolving muco-adhesive buccal films of domperidone using varying amount polyvinylpyrrolidone (PVP K-90) using the solvent casting method. Films loaded with more than 10% of drug were not homogenous and opaque as indicated by white patches of drug in the film matrix. Formulation of DMP in the film form resulted in conversion of the drug from crystalline state to the semi-crystalline state as indicated by X-ray powder diffraction analysis. Moreover, about 40% of drug loaded within the films was released during the first five minutes compared to only about only 6.5% of pure drug in drug dissolution assays in vitro. In vivo pharmacokinetics analysis revealed that the DMP-loaded film had higher maximum plasma concentration (C_max) and shorter time to reach C_max (T_max) than a commercially available tablet formulation. In conclusion, the produced DMP buccal film formulation showed high absorption rate, rapid onset of action, and improved bioavailability compared with the conventional tablet. Our findings may support the development of novel dosage forms for the transmucosal delivery of DMP for convenient, rapid, and effective treatment of nausea and vomiting.

当通过其他途径给药时，通过快速溶解膜递送药物是生物利用度低的药物的有效替代方法。多潘立酮（DMP）是一种止吐药，具有低水溶性且易受广泛的首过效应影响。为了克服这些局限性，在这项工作中，我们使用溶剂流延法设计和生产了使用不同量的聚乙烯吡咯烷酮（PVP K-90）的多潘立酮粘膜黏膜快速溶解膜。载有超过10％药物的薄膜不均匀且不透明，如薄膜基质中的白色药物斑块所示。如X射线粉末衍射分析所示，以薄膜形式的DMP制剂导致药物从结晶状态转化为半结晶状态。此外，体外。体内药代动力学分析表明，与市售片剂相比，DMP负载膜具有更高的最大血浆浓度（C _max）和更短的达到C _max（T _max）的时间。总之，与常规片剂相比，所产生的DMP颊膜制剂显示出高吸收率，快速起效和改善的生物利用度。我们的发现可能支持通过DMP粘膜递送的新型剂型的开发，以方便，快速，有效地治疗恶心和呕吐。