Cannabis sativa, like all known drugs of abuse, leads to increased dopamine activation within the mesolimbic pathway. Consequent dopamine release within terminal regions of the striatum is a powerful mediator of reward and reinforcement and patterned dopamine release is critical for associative learning processes that are fundamentally involved in addiction. The endocannabinoid system modulates dopamine release at multiple sites, and the receptors, endogenous ligands, and synthetic and metabolic enzymes of the endocannabinoid system may provide key targets for pharmacotherapies to treat disorders of motivation including addiction. Disrupting endocannabinoid signaling decreases drug-induced increases in dopamine release as well those dopamine events evoked by conditioned stimuli during reward seeking. Advances in recording techniques for dopamine are allowing unprecedented examinations of these two interacting systems and elucidating the mechanisms of endocannabinoid modulation of dopamine release in reward and addiction.

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大麻素的大脑：多巴胺释放在奖励寻求和成瘾中的作用

大麻像所有已知的滥用药物一样，导致中脑边缘途径中的多巴胺活化增加。因此，纹状体末端区域内的多巴胺释放是奖赏和强化的有力媒介，而模式化的多巴胺释放对于从根本上与成瘾有关的联想学习过程至关重要。内源性大麻素系统调节多巴胺在多个部位的释放，内源性大麻素系统的受体，内源性配体以及合成酶和代谢酶可能为药物疗法治疗包括成瘾在内的动机障碍提供关键靶点。破坏性内源性大麻素信号传导减少了药物诱导的多巴胺释放以及寻求奖励过程中条件刺激引起的那些多巴胺事件的增加。