Influenza viruses are a persistent threat to global human health. Increased susceptibility to infection and the risk factors associated with progression to severe influenza-related disease are determined by a multitude of viral, host, and environmental conditions. Decades of epidemiologic research have broadly defined high-risk groups, while new genomic association studies have identified specific host factors impacting an individual's response to influenza. Here, we review and highlight both human susceptibility to influenza infection and the conditions that lead to severe influenza disease.

中文翻译：

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人类对流感感染和严重疾病的敏感性

流感病毒是对全球人类健康的持续威胁。感染的易感性增加以及与发展为严重的流感相关疾病相关的危险因素取决于多种病毒，宿主和环境条件。数十年来的流行病学研究广泛定义了高危人群，而新的基因组关联研究已经确定了影响个体对流感反应的特定宿主因素。在这里，我们回顾并强调人类对流感感染的易感性以及导致严重流感疾病的状况。