Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virulence factor which mediates bacterial biofilm formation, eukaryotic cell infection, antibiotic resistance and immunomodulation. The characteristics of OmpA in Escherichia coli (E. coli) have been extensively studied since 1974, but only in recent years researchers started to clarify the functions of OmpA in A. baumannii. In this review, we summarized the structure and functions of OmpA in A. baumannii (AbOmpA), collected novel therapeutic strategies against it for treating A. baumannii infection, and emphasized the feasibility of using AbOmpA as a potential therapeutic target.

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外膜蛋白A（OmpA）作为鲍曼不动杆菌感染的潜在治疗靶标

鲍曼不动杆菌（鲍曼不动杆菌）是引起严重医院感染的重要机会病原体，被认为是最具威胁性的革兰氏阴性菌（GNB）。外膜蛋白A（OmpA）是GNB中外膜蛋白（OMPs）的主要成分，是介导细菌生物膜形成，真核细胞感染，抗生素抗性和免疫调节的关键毒力因子。自1974年以来，对大肠杆菌（E. coli）中OmpA的特性进行了广泛的研究，但是直到最近几年，研究人员才开始阐明OmpA在鲍曼不动杆菌中的功能。在这篇综述中，我们总结了鲍曼不动杆菌中OmpA的结构和功能（AbOmpA），收集了针对鲍曼不动杆菌感染的新型治疗策略，