Long non-coding RNAs (lncRNAs) have gained increasing attention as they exhibit highly tissue- and cell-type specific expression patterns. LncRNAs are highly expressed in the central nervous system and their roles in the brain have been studied intensively in recent years, but their roles in the spinal motor neurons (MNs) are largely unexplored. Spinal MN development is controlled by precise expression of a gene regulatory network mediated spatiotemporally by transcription factors, representing an elegant paradigm for deciphering the roles of lncRNAs during development. Moreover, many MN-related neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), are associated with RNA metabolism, yet the link between MN-related diseases and lncRNAs remains obscure. In this review, we summarize lncRNAs known to be involved in MN development and disease, and discuss their potential future therapeutic applications.

中文翻译：

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长非编码RNA在运动神经元发育和疾病中的功能作用。

长的非编码RNA（lncRNA）表现出高度的组织和细胞类型特异性表达模式，因此受到越来越多的关注。LncRNA在中枢神经系统中高度表达，近年来已对其在脑中的作用进行了深入研究，但在脊髓运动神经元（MNs）中的作用尚待进一步研究。脊髓MN的发育受转录因子介导的时空介导的基因调控网络的精确表达控制，代表了一种解密lncRNA在发育过程中作用的优雅范式。此外，许多与MN相关的神经退行性疾病，如肌萎缩性侧索硬化症（ALS）和脊髓性肌萎缩症（SMA），都与RNA代谢有关，但MN相关疾病与lncRNA之间的联系仍然不清楚。在这篇评论中