This editorial highlights advances in brain barrier and brain fluid research published in 2019, as well as addressing current controversies and pressing needs. Topics include recent advances related to: the cerebral endothelium and the neurovascular unit; the choroid plexus, arachnoid membrane; cerebrospinal fluid and the glymphatic hypothesis; the impact of disease states on brain barriers and brain fluids; drug delivery to the brain; and translation of preclinical data to the clinic. This editorial also mourns the loss of two important figures in the field, Malcolm B. Segal and Edward G. Stopa.

中文翻译：

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今年是：2019 年脑屏障和脑液研究

这篇社论重点介绍了 2019 年发表的脑屏障和脑液研究的进展，并解决了当前的争议和紧迫的需求。主题包括以下相关的最新进展：脑内皮和神经血管单元；脉络丛、蛛网膜；脑脊液和类淋巴假说；疾病状态对脑屏障和脑液的影响；药物输送到大脑；以及将临床前数据转化为临床。这篇社论还哀悼该领域两位重要人物马尔科姆·B·西格尔 (Malcolm B. Segal) 和爱德华·G·斯托帕 (Edward G. Stopa) 的去世。