Dorsomedial prefrontal cortex (dmPFC) and hippocampus (HPC) are thought to play complementary roles in a spatial working memory and decision-making network, where spatial information from HPC informs representations in dmPFC, and contextual information from dmPFC biases how HPC recalls that information. We recorded simultaneously from neural ensembles in rodent dmPFC and HPC as rats performed a rule-switching task, and found that ensembles in dmPFC and HPC simultaneously encoded task contingencies and other time-varying information. While ensembles in HPC transitioned to represent new contingencies at the same time as rats updated their strategies to be consistent with the new contingency, dmPFC ensembles transitioned earlier. Neural representations of other time-varying information also changed faster in dmPFC than in HPC. Our results suggest that HPC and dmPFC represent contingencies while simultaneously representing other information which changes over time, and that this contextual information is integrated into hippocampal representations more slowly than in dmPFC.

中文翻译：

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背侧前额叶皮层和海马体即使在整个任务过程中同时改变表示时，也代表了战略背景。

人们认为背侧前额叶皮层（dmPFC）和海马（HPC）在空间工作记忆和决策网络中起互补作用，其中HPC的空间信息通知dmPFC中的表示形式，而dmPFC的上下文信息会影响HPC回忆该信息的方式。当大鼠执行规则转换任务时，我们同时从啮齿动物dmPFC和HPC中的神经合奏记录下来，发现dmPFC和HPC中的合奏同时编码了任务偶然性和其他随时间变化的信息。当大鼠更新其策略使其与新的偶然性保持一致时，HPC中的乐团转变为代表新的意外事件，而dmPFC乐团则转变得更早。dmPFC中其他时变信息的神经表示也比HPC中的神经表示变化更快。