A poly(l-serine)-modified glassy carbon electrode (PLS/GCE) was fabricated by electropolymerization and used to study the detection of naproxen (NPX), a representative non-steroidal anti-inflammatory drug, in phosphate buffer supporting electrolyte at pH 5.0. Results indicated that the PLS/GCE was capable of determination of NPX at a working potential of 0.92 (vs. Ag/AgCl) in voltammetry mode. Experimental factors such as scan rate, accumulation time, solution pH, initial NPX concentration, and interferences were optimized for NPX determination efficiency. The morphology and elemental distribution of the electrode surface were characterized by ESEM, TEM, PSD, XRD, FTIR, TGA, XPS, and zeta potential. NPX oxidation current increased with increasing analyte concentration and scan rate but decreased with increasing pH. Linear sweep voltammetry calibration curve was established in the NPX concentration range of 4.3-65 μM, with detection limit and average recovery of 0.69 μM (n = 3) and 104 ± 2.5%, respectively. PLS/GCE is simple, accurate, reproducible, and easy for operation, therefore would be cost-effective for the determination of NPX.

中文翻译：

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使用聚（1-丝氨酸）修饰的玻碳电极对水中萘普生进行电化学分析。

通过电聚合反应制备了聚（1-丝氨酸）修饰的玻碳电极（PLS / GCE），用于研究在pH值下支持电解质的磷酸盐缓冲液中萘普生（NPX）（一种代表性的非甾体类抗炎药）的检测5.0。结果表明，PLS / GCE能够在伏安模式下以0.92（vs. Ag / AgCl）的工作电势测定NPX。实验因素如扫描速率，累积时间，溶液pH，初始NPX浓度和干扰已针对NPX测定效率进行了优化。电极表面的形貌和元素分布通过ESEM，TEM，PSD，XRD，FTIR，TGA，XPS和Zeta电位进行表征。NPX氧化电流随分析物浓度和扫描速率的增加而增加，但随pH值的增加而降低。在NPX浓度范围为4.3-65μM时建立了线性扫描伏安法校准曲线，检测限和平均回收率分别为0.69μM（n = 3）和104±2.5％。PLS / GCE简单，准确，可重现且易于操作，因此对于确定NPX具有成本效益。