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A steroid hormone agonist reduces female fitness in insecticide-resistant Anopheles populations.
Insect Biochemistry and Molecular Biology ( IF 3.2 ) Pub Date : 2020-04-08 , DOI: 10.1016/j.ibmb.2020.103372 Faye Brown 1 , Douglas G Paton 2 , Flaminia Catteruccia 2 , Hilary Ranson 1 , Victoria A Ingham 1
Insect Biochemistry and Molecular Biology ( IF 3.2 ) Pub Date : 2020-04-08 , DOI: 10.1016/j.ibmb.2020.103372 Faye Brown 1 , Douglas G Paton 2 , Flaminia Catteruccia 2 , Hilary Ranson 1 , Victoria A Ingham 1
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Insecticide based vector control tools such as insecticide treated bednets and indoor residual spraying represent the cornerstones of malaria control programs. Resistance to chemistries used in these programs is now widespread and represents a significant threat to the gains seen in reducing malaria-related morbidity and mortality. Recently, disruption of the 20-hydroxyecdysone steroid hormone pathway was shown to reduce Plasmodium development and significantly reduce both longevity and egg production in a laboratory susceptible Anopheles gambiae population. Here, we demonstrate that disruption of this pathway by application of the dibenzoylhydrazine, methoxyfenozide (DBH-M), to insecticide resistant An. coluzzii, An. gambiae sl and An. funestus populations significantly reduces egg production in both topical and tarsal application. Moreover, DBH-M reduces adult longevity when applied topically, and tarsally after blood feeding. As the cytochrome p450s elevated in pyrethroid resistant Anopheles only bind DBH-M very weakly, this compound is unlikely to be subject to cross-resistance in a field-based setting. Manipulation of this hormonal signalling pathway therefore represents a potential complementary approach to current malaria control strategies, particularly in areas where high levels of insecticide resistance are compromising existing tools.
中文翻译：
类固醇激素激动剂会降低对杀虫剂具有抗药性的按蚊种群中的雌性健康状况。
基于杀虫剂的病媒控制工具，例如经杀虫剂处理的蚊帐和室内滞留喷洒，是疟疾控制计划的基石。对这些项目中使用的化学物质的耐药性现在很普遍，并对减少疟疾相关发病率和死亡率方面取得的成果构成了重大威胁。最近，20-羟基蜕皮酮类固醇激素途径的破坏被证明可以减少疟原虫的发育，并显着降低实验室易感冈比亚按蚊群体的寿命和产蛋量。在这里，我们证明通过使用二苯甲酰肼、甲氧虫酰肼 (DBH-M) 可以破坏该途径，从而抑制杀虫剂抗性。科鲁兹，An. 冈比亚 sl 和 An。funestus 种群在局部和跗骨施用中均显着降低产卵量。此外，局部使用 DBH-M 以及喂血后跗骨使用时，DBH-M 会缩短成人寿命。由于拟除虫菊酯抗性按蚊中细胞色素 p450 升高，仅与 DBH-M 结合非常微弱，因此该化合物在田间环境中不太可能受到交叉耐药性。因此，操纵这种激素信号通路代表了当前疟疾控制策略的潜在补充方法，特别是在杀虫剂高水平耐药性正在损害现有工具的地区。
更新日期：2020-04-08
中文翻译：
类固醇激素激动剂会降低对杀虫剂具有抗药性的按蚊种群中的雌性健康状况。
基于杀虫剂的病媒控制工具，例如经杀虫剂处理的蚊帐和室内滞留喷洒，是疟疾控制计划的基石。对这些项目中使用的化学物质的耐药性现在很普遍，并对减少疟疾相关发病率和死亡率方面取得的成果构成了重大威胁。最近，20-羟基蜕皮酮类固醇激素途径的破坏被证明可以减少疟原虫的发育，并显着降低实验室易感冈比亚按蚊群体的寿命和产蛋量。在这里，我们证明通过使用二苯甲酰肼、甲氧虫酰肼 (DBH-M) 可以破坏该途径，从而抑制杀虫剂抗性。科鲁兹，An. 冈比亚 sl 和 An。funestus 种群在局部和跗骨施用中均显着降低产卵量。此外，局部使用 DBH-M 以及喂血后跗骨使用时，DBH-M 会缩短成人寿命。由于拟除虫菊酯抗性按蚊中细胞色素 p450 升高，仅与 DBH-M 结合非常微弱，因此该化合物在田间环境中不太可能受到交叉耐药性。因此，操纵这种激素信号通路代表了当前疟疾控制策略的潜在补充方法，特别是在杀虫剂高水平耐药性正在损害现有工具的地区。
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